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Dapoxetine is the most effective and safest medication for the treatment of premature ejaculation. In 2012, Dr. Chris McMahon conducted a study in which more than 6,000 men participated.

Dapoxetine is sold under the brand name Priligy in the USA.

As a result, it was concluded that dapoxetine at a dose of 30 mg to 60 mg increases the average duration of sexual intercourse from 0.9 minutes to 3.6 minutes.

Further studies have shown that dapoxetine can be successfully used in the treatment of premature ejaculation of any etymology, including genetic predisposition, and contributes to an increase in the duration of sex of up to four times.

Mode of application

The optimal starting dose of dapoxetine is 30 mg. If necessary, it may be increased to 60 mg. Patients should take the drug orally at one hour to two hours before sexual intercourse. Food does not affect the effectiveness of the tablets.

The maximum therapeutic dose should not exceed 60 mg. Exceeding this dose will not have a significant influence on the prolongation of sexual intercourse, but will increase the risk of side effects.

Individuals over the age of 65 years do not need to adjust the dose. However, in the case of renal failure, it must be reduced.

Indications and mechanism of action

Dapoxetine is prescribed in the following cases:

  • Lack of control over ejaculation
  • Premature ejaculation in most attempts at sexual intercourse in the last six months

The main active ingredient of the drug is dapoxetine hydrochloride, which belongs to the group of selective serotonin reuptake inhibitors. Dapoxetine inhibits the reuptake of serotonin by neurons, enhancing the effect of neurotransmitters on synaptic receptors.


Before purchasing dapoxetine in a pharmacy, patients must know the contraindications for the medicine, which include:

  • Hypersensitivity to the drug
  • Age younger than 18 years
  • Heart failure
  • Severe ischemic heart disease
  • Severe disorders of the kidneys and liver
  • Epilepsy
  • Parkinson’s disease

Dapoxetine should not be taken at the same time as narcotic painkillers, monoamine oxidase inhibitors, antifungal drugs, tricyclic antidepressants, or migraine drugs.

Dapoxetine and alcohol

There is no information about the adverse effects of dapoxetine and alcohol available at this time. Ethanol does not violate the absorption of the drug. However, drinking alcohol and dapoxetine may increase the risk of side effects associated with the drug.

Side effects

Dapoxetine is usually well-tolerated by the body. The percentage of men who have side effects after taking the drug is minimal. In most cases, patients reported nausea, dizziness, headache, diarrhea, and sleepiness as side effects.

As a rule, side effects appear at 1.5 hours after taking the medication, when the dapoxetine concentration in the blood reaches its peak. They can last for up to one and a half hours thereafter and, if necessary, require symptomatic therapy for resolution.

Side effects were observed in less than 3% of men who took this medicine.