Priligy drug is intended for the medical treatment of premature ejaculation and is available in the form of tablets for oral consumption.
The drug is used by men in whom the time of intravaginal sex is less than two minutes and who cannot control the process of ejaculation.
According to statistics, such deviations occur in 40% of men in the world under the age of 50 years.
Currently, Priligy is the only drug for the treatment of premature ejaculation and is officially approved by the World Health Organization.
The drug was initially developed by the pharmaceutical company Eli Lilly and Company (Indianapolis, IN, USA), as a new medicine for the treatment of depression. However, the medication did not work for these purposes because it did not meet the requirements for this group of medicines.
The main reason for its failure was that the active substance of the drug, dapoxetine, has too much of a half-life and was not cumulated in the body. However, subsequent studies found another useful quality of the drug: the ability to prevent early ejaculation.
Priligy pills is now sold in more than 50 countries in Europe and Asia and, in the United States, is undergoing the final stage of clinical research.
Mode of application
Studies have shown that Priligy pills is best taken at one to three hours before intercourse, without chewing and with drinking plenty of water. Priligy is equally effective when taken with or without food. However, in the latter case, nausea symptoms may be more common in some men.
Recommended dosages of Priligy range from 30 mg to 60 mg. Studies have established a dose-dependent effect on delayed ejaculation. On average, 60 mg of dapoxetine had a 30% better latency than 30 mg and a 70% better latency than the group of men taking a placebo. However, increasing the dosage can also increase the possibility of side effects.
Mechanism of action
The action of Priligy is based on the processes of inhibiting the reverse neuronal uptake of serotonin and increasing its concentration in the synaptic cleft between neurons. Medical research on antidepressants revealed a positive correlation between the increase in serotonin concentration and the increase in intravaginal ejaculation time.
Unlike other similar drugs from the group of selective serotonin reuptake inhibitors, Priligy acts much faster, is safer, and also has no adverse effect on libido. In clinical studies, Priligy was effective in 96% of men.
Common side effects of Priligy may include dry mouth, nausea, dizziness, headache, diarrhea, and insomnia.
Patients should refuse to take drugs that act on the serotonin system simultaneously in conjunction with Priligy. These include MAO inhibitors, tricyclic antidepressants, lithium, diphenhydramine, and others.
Some medications such as ketoconazole, erythromycin, and ritonavir can influence the pharmacokinetics and metabolism of Priligy, thereby increasing the risk of side effects.